تفاعل #619087

معادلة التفاعل

water

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea

NCS

→

3-(5-Chloro-thiazol-2-yl)-1-cyclohexyl-1-piperidin-1-yl-urea

المذيبات

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   تجفيفThe organic phase was dried (MgSO4)
3. 3
   أخرىthe solvent was removed in vacuo
4. 4
   workup.ADDITIONMeCN (1 mL) was added whereupon the product
5. 5
   أخرىprecipitated
6. 6
   ترشيحThe product was filtered off
7. 7
   أخرىdried

الإجراء التجريبي

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea (50 mg, 0.16 mmol), prepared in an identical manner to Example 94 was dissolved in DCM (1 mL) and NCS (26 mg, 0.19 mmol)) was added. The reaction mixture was stirred for 3 days before DCM (20 mL) and water (20 mL) was added. The organic phase was dried (MgSO4) and the solvent was removed in vacuo. MeCN (1 mL) was added whereupon the product precipitated. The product was filtered off and dried. Yield: 20 mg.

المصدر