تفاعل #619083

معادلة التفاعل

Dicyclohexylamine

aminothiazole

carbonyldiimidazole

→

title product

1,1-Dicyclohexyl-3-thiazol 2 yl urea

المذيبات

ethyl acetate

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe reaction stirred overnight at room temperature
2. 2
   غسيلwashed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL)
3. 3
   تجفيفdried over magnesium sulphate
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىthe residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min)

الإجراء التجريبي

To a solution of aminothiazole (50 mg, 0.5 mmol) in dichloromethane was added carbonyldiimidazole (81 mg, 0.5 mmol) and the solution stirred 2 h at room temperature. Dicyclohexylamine (1 eq) was then added and the reaction stirred overnight at room temperature. The reaction mixture is then diluted with ethyl acetate (8 mL), washed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL), dried over magnesium sulphate, concentrated in vacuo, and the residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min) to give the title product (52 mg).

المصدر