تفاعل #618831

معادلة التفاعل

tert-butyl 4-(4-(3-(1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate

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titled compound

المردود 11.2%

5-(4-(piperidin-4-yl)phenyl)-3-(1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

المردود 11.2%

المذيبات

TFA DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىreaction conditions

الإجراء التجريبي

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (110 mg, 0.205 mmol) was deprotected in TFA/DCM (5/5 ml). This afforded 10 mg (11.1% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.73 (s, 1H), 8.68-8.67 (d, 1H), 8.59 (s, 1H), 8.38 (s, 1H), 8.16-8.11 (t, 1H), 8.01 (s, 1H), 7.81 (s, 1H), 7.75-7.72 (d, 2H), 7.66-7.61 (t, 1H), 7.49-7.42 (m, 3H), 5.68 (s, 2H), 3.55-3.51 (d, 2H), 3.21-3.13 (m, 2H), 3.03-2.95 (m, 1H), 2.14-1.90 (m, 4H). MS: m/z=434.9 (M+1), HPLC: 92.12% in method A.

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