تفاعل #618809

معادلة التفاعل

step-iii

3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(4-(piperidin-4-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride

tert-butyl 4-(2-fluoro-4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate

lithium hydroxide

→

titled compound

المردود 76.3%

tert-butyl 4-(2-fluoro-4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate

المردود 76.3%

المذيبات

THF methanol water

ظروف التفاعل

المعالجة

1. 1
   أخرىreaction conditions

الإجراء التجريبي

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(2-fluoro-4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (250 mg, 0.345 mmol) was hydrolyzed by lithium hydroxide (73 mg, 1.726 mmol) in THF/methanol/water (5/2/1 ml) to yield crude 150 mg (76.14% yield) of the titled compound. MS: m/z=570.2 (M+1).

المصدر