تفاعل #61825

معادلة التفاعل

water

3-Chloromethyl-6-(2-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyridine

4-(4-[1,2,3]triazol-1-yl-butyl)phenol

sodium hydride

→

title compound

المردود 77.3%

6-(2-Fluoro-4-trifluoromethyl-phenyl)-2-methyl-3-[4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-pyridine

المردود 77.3%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred
2. 2
   workup.WAITover night
3. 3
   أخرىthe precipitate was isolated
4. 4
   غسيلwashed thoroughly with water and diisopropylether
5. 5
   أخرىThe residue was dried at 40° C.

الإجراء التجريبي

A solution of 359 mg (1.65 mmol) 4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 20.0 ml N,N-dimethylformamide was treated at 0° C. with 66 mg (1.65 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 500 mg (1.65 mmol) 3-Chloromethyl-6-(2-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyridine were added and stirred continued at r. t. over night. After addition of 40 ml water, the precipitate was isolated, washed thoroughly with water and diisopropylether. The residue was dried at 40° C. to give 618 mg (77%) of the title compound as light brown powder.

المصدر