تفاعل #61824

معادلة التفاعل

water

3-Chloromethyl-6-(2-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyridine

3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)phenol

sodium hydride

→

title compound

المردود 76.0%

6-(2-Fluoro-4-trifluoromethyl-phenyl)-2-methyl-3-[3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-pyridine

المردود 76.0%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred
2. 2
   workup.WAITover night
3. 3
   أخرىthe precipitate was isolated
4. 4
   غسيلwashed thoroughly with water and diisopropylether
5. 5
   أخرىThe residue was dried at 40° C.

الإجراء التجريبي

A solution of 153 mg (0.66 mmol) 3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 8.0 ml N,N-dimethylformamide was treated at 0° C. with 26 mg (0.66 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 200 mg (0.66 mmol) 3-Chloromethyl-6-(2-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyridine were added and stirred continued at r. t. over night. After addition of 16 ml water, the precipitate was isolated, washed thoroughly with water and diisopropylether. The residue was dried at 40° C. to give 250 mg (76%) of the title compound as light brown powder.

المصدر