تفاعل #61773

معادلة التفاعل

water

3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine

4-(2-[1,2,3]triazol-1-yl-ethanesulfinylmethyl)-phenol

sodium hydride

→

title compound

المردود 52.0%

2-Methyl-3-[4-(2-[1,2,3]triazol-1-yl-ethanesulfinylmethyl)-phenoxymethyl]-6-(4-trifluoromethyl-phenyl)-pyridine

المردود 52.0%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITcontinued over night
3. 3
   أخرىthe precipitate was isolated
4. 4
   غسيلwashed thoroughly with water, methanol/water 1:1
5. 5
   أخرىThe residue was purified by chromatography on silica (eluent: ethyl acetate/methanol 9:1)

الإجراء التجريبي

A solution of 126 mg (mmol) 4-(2-[1,2,3]triazol-1-yl-ethanesulfinylmethyl)-phenol in 4.0 ml N,N-dimethylformamide was treated at 0° C. with 14 mg (0.55 mmol) of 95% sodium hydride and stirred at 0° C. for 30 min., then 143 mg (0.50 mmol) 3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine were added and stirring continued over night. After addition of 8 ml water, the precipitate was isolated, washed thoroughly with water, methanol/water 1:1, and a small amount of ether. The residue was purified by chromatography on silica (eluent: ethyl acetate/methanol 9:1) to give 130 mg (52%) of the title compound as white powder.

المصدر