تفاعل #61763

معادلة التفاعل

water

sodium hydride

3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol

3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine

→

title compound

المردود 63.0%

2-Methyl-3-[3-Methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-6-(4-trifluoromethyl-phenyl)-pyridine

المردود 63.0%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirring
2. 2
   أخرىcontinued at room temperature
3. 3
   أخرى(r.t.) overnight
4. 4
   workup.STIRRINGwas stirred for 1 h
5. 5
   أخرىthe formed precipitate isolated by filtration
6. 6
   غسيلwashed with water, water/methanol 1:1, and ether
7. 7
   أخرىThe residue was purified by chromatography on silica (eluent: ethyl acetate)

الإجراء التجريبي

36 mg (0.90 mmol) of 95% sodium hydride were added to at 0° C. to a solution of 173 mg (0.75 mmol) 3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol in 4.0 ml N,N-dimethylformamide and stirred for 30 min. at 0° C. 214 mg (0.75 mmol) 3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (WO 2005/049573) were given to the reaction mixture and stirring continued at room temperature (r.t.) overnight. After addition of 8 ml water the mixture was stirred for 1 h, the formed precipitate isolated by filtration, washed with water, water/methanol 1:1, and ether. The residue was purified by chromatography on silica (eluent: ethyl acetate) to yield 227 mg (63%) of the title compound as white crystals.

المصدر