تفاعل #61728

معادلة التفاعل

1-(4-chlorophenyl)ethane-1-one

N,N Dimethylformamide diisopropylacetal

→

title compound

المردود 99.0%

(2E)-3-Dimethylamino-1-(4-chlorophenyl)prop-2-en-1-one

المردود 99.0%

المذيبات

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for 16 hours
2. 2
   ترشيحThe resulting solid was collected via filtration
3. 3
   غسيلwashed with hexanes

الإجراء التجريبي

A solution of 1-(4-chlorophenyl)ethane-1-one (35.0 g, 226 mmol) and N,N Dimethylformamide diisopropylacetal (35 mL) was heated to reflux for 16 hours. The reaction mixture was cooled to room temperature and treated with hexanes (50 mL). The resulting solid was collected via filtration and washed with hexanes to provide the title compound as a yellow solid (47.12 g, 99% yield): HPLC Retention Time; 6.45 min (Method B). M+1; 209.

المصدر