تفاعل #61655

معادلة التفاعل

ethyl acetate

2-bromo-2-methyl-propionyl chloride

1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone

hydrochloric acid

→

N-(3-acetyl-5-benzyloxy-2-hydroxy-phenyl)-2-bromo-2-methyl-propionamide

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter the addition
2. 2
   أخرىThe organic phase is separated off
3. 3
   غسيلwashed with water
4. 4
   تجفيفdried with sodium sulphate
5. 5
   workup.DISTILLATIONAfter the solvent has been distilled off the residue
6. 6
   أخرىis crystallised from a diethyl ether/petroleum ether mixture

الإجراء التجريبي

4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise at 5 to 20° C. to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried with sodium sulphate. After the solvent has been distilled off the residue is crystallised from a diethyl ether/petroleum ether mixture.

المصدر