تفاعل #61549

معادلة التفاعل

water

2-Bromo-N-(5-chloro-pyridin-2-yl)-acetamide

5-[2-(2-Methoxy-ethoxy)-ethoxy]-2H-pyrazole-3-carboxylic acid ethyl ester

sodium hydride

→

2-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-[2-(2-methoxy-ethoxy)-ethoxy]-2H-pyrazole-3-carboxylic acid ethyl ester

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe reaction was stirred at room temperature for 2 h
2. 2
   استخلاصthe mixture was extracted with DCM (3×100 ml)
3. 3
   تجفيفThe combined organic layers were dried over MgSO4
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated under reduced pressure
6. 6
   أخرىThe product was used in the next reaction step without further purification

الإجراء التجريبي

To a solution of 1 g 5-[2-(2-Methoxy-ethoxy)-ethoxy]-2H-pyrazole-3-carboxylic acid ethyl ester in 10 ml of DMF and 154 mg of sodium hydride (60% in mineral oil) were added at RT. After stirring for 5 min at room temperature, 966 mg of 2-Bromo-N-(5-chloro-pyridin-2-yl)-acetamide were added. The reaction was stirred at room temperature for 2 h. Then 50 ml of water were added and the mixture was extracted with DCM (3×100 ml). The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The product was used in the next reaction step without further purification. Yield: 1.2 g.

المصدر