تفاعل #61523

معادلة التفاعل

5-Chloro-pyridin-2-ylamine

pyridine

bromo-acetyl bromide

→

2-Bromo-N-(5-chloro-pyridin-2-yl)-acetamide

المذيبات

toluene

toluene

toluene

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added dropwise under ice cooling
2. 2
   أخرىAfter 2 h the precipitate was isolated by filtration
3. 3
   أخرىto yield a white solid

الإجراء التجريبي

To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 ml pyridine in 30 ml toluene, 8 g bromo-acetyl bromide dissolved in 10 ml toluene was added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recristallized from toluene to yield a white solid.

المصدر