تفاعل #61519

معادلة التفاعل

Piperidin-4-yl-carbamic acid tert-butyl ester

4-Chloropyridine

→

(3,4,5,6-Tetrahydro-2H-[1,4′]bipyridinyl-4-yl)-carbamic acid tert-butyl ester

المذيبات

DCM

n-butanol water NEt3

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with NaHCO3 solution and water
2. 2
   تجفيفThe organic layer was dried over Na2SO4
3. 3
   ترشيحfiltered
4. 4
   أخرىthe solvent was removed under reduced pressure
5. 5
   أخرىChromatographic purification of the residue on silica with DCM as eluent
6. 6
   أخرىgave
7. 7
   أخرىafter evaporation of the fractions
8. 8
   workup.ADDITIONcontaining the product a white foam

الإجراء التجريبي

A solution of 3 g Piperidin-4-yl-carbamic acid tert-butyl ester and 2.5 g 4-Chloropyridine in 9 ml n-butanol/water/NEt3 1:1:1 was heated at 100° C. for 48 h. Then the solution was cooled to RT diluted with DCM and washed with NaHCO3 solution and water. The organic layer was dried over Na2SO4, filtered, and the solvent was removed under reduced pressure. Chromatographic purification of the residue on silica with DCM as eluent gave after evaporation of the fractions containing the product a white foam. Yield 1.7 g.

المصدر