تفاعل #61504

معادلة التفاعل

2-Methyl-quinoline-6-carboxylic acid N′-(4-[1,3] dioxan-2-yl-1-methylimino-butyl)-hydrazide

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title compound

المردود 10.0%

6-[5-(3-[1,3] Dioxan-2-yl-propyl)-4-methyl-4H-[1,2,4] triazol-3-yl]-2-methyl-quinoline

المردود 10.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   أخرىthe residue was purified by silica gel chromatography (eluent 20% MeOH:EtOAc) which

الإجراء التجريبي

2-Methyl-quinoline-6-carboxylic acid N′-(4-[1,3] dioxan-2-yl-1-methylimino-butyl)-hydrazide (1.28 g, 3.4 mmol) was heated in ethyl acetate (20 ml) for 4 h. The solvent was evaporated and the residue was purified by silica gel chromatography (eluent 20% MeOH:EtOAc) which gave the title compound as a brown solid (109 mg, 10%).

المصدر