تفاعل #614846

معادلة التفاعل

2-chloro-5-nitropyridine

2,2-dimethyl-2,3-dihydro-1-benzofuran-4-ol

potassium carbonate

→

title compound

المردود 68.8%

2-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-5-nitropyridine

المردود 68.8%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was heated under microwave irradiation for 1 hour at 110 C
2. 2
   ترشيحThe reaction mixture was filtered
3. 3
   غسيلThe filtrated solid was washed with dichloromethane (5 ml)
4. 4
   أخرىThe volatiles were evaporated under vacuum
5. 5
   workup.DISSOLUTIONThe crude compound was dissolved in dichloromethane (8 ml)
6. 6
   workup.ADDITIONbrine was added (8 ml)
7. 7
   استخلاصThe compound was extracted 2 times with dichloromethane (2×8 ml) and 2 times with ethylacetate (2×8 ml)
8. 8
   تجفيفCombined organic layers were dried over sodium sulphate
9. 9
   أخرىevaporated
10. 10
    أخرىThe residue was purified by silica gel chromatography (Companion system, 12 g Si cartridge) with cyclohexane/ethyl acetate from 100:0 to 80:20 as eluents

الإجراء التجريبي

In a microwave vial, 2-chloro-5-nitropyridine (97 mg, 0.609 mmol) was dissolved in 3 mL of dimethylformamide. 2,2-dimethyl-2,3-dihydro-1-benzofuran-4-ol (100 mg, 0.609 mmol) and potassium carbonate (253 mg, 1.827 mmol) were added. The reaction mixture was heated under microwave irradiation for 1 hour at 110 C. The reaction mixture was filtered. The filtrated solid was washed with dichloromethane (5 ml). The volatiles were evaporated under vacuum. The crude compound was dissolved in dichloromethane (8 ml) and brine was added (8 ml). The compound was extracted 2 times with dichloromethane (2×8 ml) and 2 times with ethylacetate (2×8 ml). Combined organic layers were dried over sodium sulphate and evaporated. The residue was purified by silica gel chromatography (Companion system, 12 g Si cartridge) with cyclohexane/ethyl acetate from 100:0 to 80:20 as eluents affording the title compound (120 mg).

المصدر