تفاعل #61468

معادلة التفاعل

6-chloro-2-piperazin-1-yl-quinoline hydrochloride

5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid

ethyl acetate

→

title compound

[4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone

المذيبات

acetonitrile

ظروف التفاعل

الإجراء التجريبي

Prepared in analogy to example 1.1 b) from 6-chloro-2-piperazin-1-yl-quinoline hydrochloride (Example 1.20b) and 5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (Example 2.7) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid.

المصدر