تفاعل #61452

معادلة التفاعل

2-chloroquinoxaline

piperazine-1-carboxylic acid tert-butyl ester

potassium carbonate

potassium iodide

→

4-Quinoxalin-2-yl-piperazine-1-carboxylic acid tert.-butyl Ester

المذيبات

water

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed overnight
2. 2
   درجة الحرارةThe reaction mixture was cooled
3. 3
   استخلاصextracted 3 times with ethyl acetate
4. 4
   أخرىThe organic phase was dried
5. 5
   أخرىevaporated
6. 6
   أخرىthe title compound was crystallised from methanol

الإجراء التجريبي

A mixture of 9.1 mmol 2-chloroquinoxaline, 10.0 mmol piperazine-1-carboxylic acid tert-butyl ester, 22.8 mmol potassium carbonate and 2.1 mmol potassium iodide in 20 ml of toluene was refluxed overnight. The reaction mixture was cooled, poured into water and extracted 3 times with ethyl acetate. The organic phase was dried, evaporated and the title compound was crystallised from methanol. Yellowish solid.

المصدر