تفاعل #6111

معادلة التفاعل

4-(4-iodophenyl)benzonitrile

sodium thiomethylate

→

pale yellow solid

المردود 106.6%

4-(4-mercaptophenyl)benzonitrile

المردود 106.6%

المذيبات

hexamethylphosphoramide

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe expected product is extracted with ethyl acetate
2. 2
   غسيلThe resulting organic phase is washed with water until the pH of the washings
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   أخرىevaporated under reduced pressure

الإجراء التجريبي

3.25 g (10.8.10-3 mol) of 4-(4-iodophenyl)benzonitrile are dissolved in 50 ml of hexamethylphosphoramide, and 3.05 g (43.4.10-3 mol) of sodium thiomethylate are then added to the solution. The reaction mixture is heated at 100° C. for 1.5 hours and then, after cooling, hydrolyzed in a 1 N hydrochloric acid/ice mixture. The expected product is extracted with ethyl acetate. The resulting organic phase is washed with water until the pH of the washings is neutral, dried over magnesium sulfate and then evaporated under reduced pressure to give 2.4 g (quantitative yield) of a pale yellow solid.

المصدر