تفاعل #61078

معادلة التفاعل

6-bromo-2-pyridinamine

1-chloro-2-isocyanatoethane

→

title compound

المردود 66.0%

N-(6-Bromo-2-pyridinyl)-N′-(2-chloroethyl)urea

المردود 66.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe crude mixture was partitioned between CH2Cl2 and water
2. 2
   أخرىThe phases were separated
3. 3
   تجفيفthe organic layer was dried over anh. Na2SO4
4. 4
   ترشيحThe solids were filtered
5. 5
   أخرىthe solvent evaporated

الإجراء التجريبي

To a solution of 6-bromo-2-pyridinamine (1 g, 5.78 mmol) in anh. THF (25 mL), at r.t., under N2, was added 1-chloro-2-isocyanatoethane (1.2 mL, 2.5 eq) and the reaction mixture was stirred at r.t. for 18 hr. The crude mixture was partitioned between CH2Cl2 and water. The phases were separated and the organic layer was dried over anh. Na2SO4. The solids were filtered and the solvent evaporated to give the title compound (1.06 g, 66%) which was used in the next step without further purification.

المصدر