تفاعل #61071

معادلة التفاعل

3-aminopyrazole

NaHCO3

Ac2O

→

solid

N-1H-Pyrazol-3-ylacetamide

المذيبات

H2O

ظروف التفاعل

المعالجة

1. 1
   أخرىat 5-10° C.
2. 2
   درجة الحرارةThe reaction mixture was refluxed for 8 hr
3. 3
   workup.WAITwas left
4. 4
   أخرىcrystallization
5. 5
   ترشيحThe white solid was filtered (12.9 g)

الإجراء التجريبي

To a solution of 3-aminopyrazole (20 g, 0.24 mol) in H2O (36 mL), at 5-10° C., was slowly added NaHCO3 (9.1 g, mol, 3 eq) and then Ac2O (6.79 ml, 2 eq). The reaction mixture was refluxed for 8 hr. It was cooled down to r.t. and was left standing at this temperature for 12 hr to allow crystallization. The white solid was filtered (12.9 g) and the mother liquor volume was reduced. A second batch of white solid (3.4 g) was obtained after crystallization. The two batches were combined to give the title compound (16.3 g, 54%).

المصدر