تفاعل #61036

ord-993dced8c83348ca91f3b6df02c8c962

معادلة التفاعل

CS(=O)(=O)c1ccc(I)c(C(=O)O)c1
2-Iodo-5-methanesulfonyl-benzoic acid
N#Cc1ccc(N2CCNCC2)c(F)c1
3-Fluoro-4-piperazin-1-yl-benzonitrile
→
CS(=O)(=O)c1ccc(I)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1
3-Fluoro-4-[4-(2-iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

المتفاعلات

CS(=O)(=O)c1ccc(I)c(C(=O)O)c1
2-Iodo-5-methanesulfonyl-benzoic acid
N#Cc1ccc(N2CCNCC2)c(F)c1
3-Fluoro-4-piperazin-1-yl-benzonitrile

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Example CL was prepared in analogy to Example 123 from 2-Iodo-5-methanesulfonyl-benzoic acid (example BQ) and 3-Fluoro-4-piperazin-1-yl-benzonitrile (WO9625414). MS (m/e): 514.0 (M+H+, 100%).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07427612B2uspto-grants-2008_09