تفاعل #609814

معادلة التفاعل

tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate

HCl dioxane

→

5-bromo-2-(piperazin-1-yl)pyrimidine HCl salt

المردود 94.0%

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated

الإجراء التجريبي

A solution of tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate (5 g, 14.6 mmol) in 4 M HCl-dioxane (50 mL) was stirred at room temperature for 1 hour. The reaction mixture was concentrated to give 5-bromo-2-(piperazin-1-yl)pyrimidine HCl salt (crude, 3.3 g, 94%) as a white solid. MS (ES+) C8H11BrN4 requires: 242, 244, found: 243, 245 [M+H]+.

المصدر