تفاعل #609375

معادلة التفاعل

4-Nitro-benzoic acid 1-hexyl-11-(4-nitro-phenoxy carbonyl)-undecyl ester

→

4-amino-benzoic acid 11-(4-amino-phenoxycarbonyl)-1-hexyl-undecyl ester

المذيبات

Ethyl acetate

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىtaken in a pressure vessel
2. 2
   أخرىThe catalyst was removed by filtration
3. 3
   workup.DISTILLATION75% of the solvent was distilled off
4. 4
   workup.ADDITIONpoured into cold water (2 L)
5. 5
   ترشيحThe resulting solid was filtered off
6. 6
   غسيلwashed with chilled water (100 mL)
7. 7
   ترشيحfiltered off
8. 8
   أخرىdried the material properly in vacuum oven at 60-80° C.

الإجراء التجريبي

To a solution of 4-Nitro-benzoic acid 1-hexyl-11-(4-nitro-phenoxy carbonyl)-undecyl ester (290 g) in a mixture of Ethyl acetate (1.5 L) and DMF (300 mL) taken in a pressure vessel was added Raney Nickel (80 g). The reaction mixture was stirred under an atmosphere of Hydrogen (8-10 Kg) for 4 hours at a temperature of 60-65° C. The catalyst was removed by filtration. 75% of the solvent was distilled off and poured into cold water (2 L). The resulting solid was filtered off and washed with chilled water (100 mL) and do the slurry with 1 lit diisopropylether and filtered off, then dried the material properly in vacuum oven at 60-80° C. to yield pure 4-amino-benzoic acid 11-(4-amino-phenoxycarbonyl)-1-hexyl-undecyl ester product as off white powder (190 g) with a melting point of 156-159° C. The resulting compound was characterized by 1H NMR (CDCl3) δ 0.83 (t, 3H, CH3), 1.2-1.65 (m, 26H, 13×CH2), 1.81 (m, 2H, CH2), 2.12 (t, 2H, COCH2), 3.50 (m, 1H, CH), 5.5-6.1 (m, 4H, 2×NH2) 6.8-7.2 (m, 4H, Ar), 7.2-7.8 (m, 4H, Ar). The hydrolytic degradation of the compound was carried out in pH 9.0 buffer solution. The study showed that 1% solution is 100% hydrolyzed in 15 hours at 50° C.

المصدر