تفاعل #60770

ord-534534f0c63546078f699d706b25b0ca

معادلة التفاعل

[N-]=C=O
isocyanate
CNc1ccc(N2CN=c3sccc3=C2N)cc1
4-amino-3-(4-(methylamino)phenyl)-thieno[2,3-d]pyrimidine
O=C=Nc1cc(C(F)(F)F)ccc1F
2-fluoro-5-trifluoromethyl-phenyl isocyanate
CN(C(=O)Nc1cc(C(F)(F)F)ccc1F)c1ccc(N2CN=c3sccc3=C2N)cc1
4-Amino-3-(4-((2-fluoro-5-(trifluoromethyl)phenyl)-aminocarbonyl(N-methylamino))phenyl)thieno[2,3-d]pyrimidine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىThe compound was prepared

الإجراء التجريبي

The compound was prepared following the procedure described in Example 429, substituting 4-amino-3-(4-(methylamino)phenyl)-thieno[2,3-d]pyrimidine as the amine and using 2-fluoro-5-trifluoromethyl-phenyl isocyanate as the isocyanate of choice. MH+=462.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07427623B2uspto-grants-2008_09