تفاعل #60754

ord-6b5fd8f9879e4964b2d6dcae9287a2f7

معادلة التفاعل

COc1ccc(F)c(N=C=O)c1
2-fluoro-5-methoxyphenyl isocyanate
[N-]=C=O
isocyanate
NC1=c2ccoc2=NCN1c1cccc(N)c1
4-Amino-3-(3-aminophenyl)furo[2,3-d]pyrimidine
COc1ccc(F)c(N(C(N)=O)c2ccc(N3CN=c4occc4=C3N)cc2)c1
4-Amino-3-(4-((2-fluoro-5-methoxyphenyl)-aminocarbonylamino)phenyl)furo[2,3-d]pyrimidine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىThe compound was prepared

الإجراء التجريبي

The compound was prepared following the procedure described in Example 232(b), using 2-fluoro-5-methoxyphenyl isocyanate as the isocyanate of choice, and 4-Amino-3-(3-aminophenyl)furo[2,3-d]pyrimidine (10) as the diamine of choice. MS(ES) m/e 394 [M+H]+.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07427623B2uspto-grants-2008_09