تفاعل #607493

معادلة التفاعل

4-bromo-2-fluorobenzoic acid

oxalyl chloride

DMF

→

4-bromo-2-fluorobenzoyl chloride

المردود 100.1%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   تركيزThe mixture was concentrated under reduced pressure

الإجراء التجريبي

To a solution of 4-bromo-2-fluorobenzoic acid 144a (250 g, 1.14 mol) in dry DCM (2000 mL) was added oxalyl chloride (446 g, 3.51 mol) and DMF (10 mL) at RT, and the reaction mixture was stirred at RT for 1 h. See FIG. 3. The mixture was concentrated under reduced pressure to give 4-bromo-2-fluorobenzoyl chloride 144b (271 g, 100%) as a yellow solid, which was used for the next step without further purification.

المصدر