تفاعل #607487

معادلة التفاعل

137g

3-(1,3-dioxoisoindolin-2-yl)propanoic acid

oxalyl chloride

DMF

→

3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride

المردود 92.5%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىUpon reaction completion
2. 2
   تركيزthe mixture was concentrated

الإجراء التجريبي

To a solution of 137g (20.0 g, 91 mmol) in DCM (250 mL) were added oxalyl chloride (13.8 g, 109 mmol) and DMF (0.1 mL). See FIG. 2. The mixture was stirred at RT for 4 h. Upon reaction completion, the mixture was concentrated to give 3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 137h (20.0 g, 92%) as a white solid.

المصدر