تفاعل #607468

معادلة التفاعل

2-ethyl-3-(2-hydroxyethyl)quinazoline-4 (3H)-one

thionyl chloride

chloroform

→

3-(2-chloroethyl)-2-ethylquinazoline-4 (3H)-one

المردود 32.8%

المذيبات

hexane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction medium was heated
2. 2
   درجة الحرارةto reflux
3. 3
   أخرىthe reaction, which
4. 4
   workup.ADDITIONwere added
5. 5
   أخرىto precipitate the product
6. 6
   ترشيحfiltered
7. 7
   غسيلwashed with two portions of hexane
8. 8
   أخرىdried

الإجراء التجريبي

2-ethyl-3-(2-hydroxyethyl)quinazoline-4 (3H)-one (5.00 g; 22.91 mmol) and thionyl chloride (1.672 mL, 22.91 mmol) were added to a 150 mL reactor, together with 60 mL of chloroform. The reaction medium was heated to reflux and for completing the reaction, which was accompanied through CG/MS. After the end of the reaction, 100 mL of hexane were added and the solution was agitated at room temperature in order to precipitate the product. The resulting suspension was vacuum filtered, washed with two portions of hexane and dried, yielding 3-(2-chloroethyl)-2-ethylquinazoline-4 (3H)-one as a white solid (1.78 g; 7.52 mmol; yield: 32.8%).

المصدر