تفاعل #607458

ord-1df9c2a8030f4e2683f6d2d94be875ff

معادلة التفاعل

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
Apomorphine

المتفاعلات

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride

الكواشف

لا شيء

المذيبات

O
water

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    workup.ADDITIONmixed thoroughly (i.e.
  2. 2
    workup.STIRRINGthe mixture was again homogenized
  3. 3
    workup.ADDITIONby addition of a suitable acid
  4. 4
    workup.ADDITIONThe solution is then poured onto a sheet
  5. 5
    أخرىdried in a heated oven

الإجراء التجريبي

Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US09326981B2uspto-grants-2016_05