تفاعل #607447

معادلة التفاعل

DIAD

3-bromo-6-methyl-5-nitro-pyridin-2-ol

2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethanol

triphenylphosphine

→

title compound

المردود 41.0%

5-Bromo-2-methyl-3-nitro-6-[2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethoxy]pyridine

المردود 41.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added at room temperature under inert atmosphere (Ar)
2. 2
   أخرىthe temperature below 40° C
3. 3
   أخرىwas consumed
4. 4
   أخرىto reach room temperature
5. 5
   أخرىbefore quenching with water (10 mL)
6. 6
   استخلاصThe water phase was extracted with ethyl acetate (2×50 mL)
7. 7
   غسيلThe organic layer was washed with brine (20 mL)
8. 8
   تجفيفdried over anhydrous Na2SO4
9. 9
   ترشيحfiltered
10. 10
    أخرىThe solvent was removed in vacuo
11. 11
    أخرىto give a brown residue, which
12. 12
    أخرىwas purified by combiflash column chromatography (silica gel, heptane/ethyl acetate, v/v=95/5)
13. 13
    workup.ADDITIONFractions containing the pure compound
14. 14
    أخرىwere collected
15. 15
    تركيزconcentrated in vacuo

الإجراء التجريبي

To a stirring suspension of 3-bromo-6-methyl-5-nitro-pyridin-2-ol (0.25 g, 1.07 mmol) in THF (7 mL), 2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethanol (0.39 g, 1.61 mmol, 1.5 equiv) and triphenylphosphine (0.42 g, 1.61 mmol, 1.5 eq) were added at room temperature under inert atmosphere (Ar). To this mixture, DIAD (diisopropyl diazodicarboxylate) (0.33 mL, 1.61 mmol, 1.5 eq) was added dropwise over 10 minutes while keeping the temperature below 40° C. The reaction mixture was stirred for 6 h under heating at 60° C. After this time, TLC indicted that the starting material was consumed and the reaction mixture was allowed to reach room temperature before quenching with water (10 mL). The water phase was extracted with ethyl acetate (2×50 mL). The organic layer was washed with brine (20 mL), dried over anhydrous Na2SO4 and filtered. The solvent was removed in vacuo to give a brown residue, which was purified by combiflash column chromatography (silica gel, heptane/ethyl acetate, v/v=95/5). Fractions containing the pure compound were collected and concentrated in vacuo to give the title compound (0.18 g, 41% yield) as a yellow oil.

المصدر