تفاعل #60725

معادلة التفاعل

(R)-2-(1-isopropylpiperidin-4-ylmethoxy)-1-phenylethylamine

4-methoxybenzoyl chloride

→

N-[(R)-2-(1-Isopropylpiperidine-4-ylmethoxy)-1-phenylethyl]-4-methoxybenzamide hydrochloride

ظروف التفاعل

المعالجة

1. 1
   أخرىafforded
2. 2
   أخرىafter purification (SiO2: 4:2:1 DCM:EtOAc:isopropyl-amine) and conversion to the HCl salt by general method A, 205 mg (91%) of the title compound

الإجراء التجريبي

Using coupling method B, (R)-2-(1-isopropylpiperidin-4-ylmethoxy)-1-phenylethylamine (150 mg, 0.54 mmol) and 4-methoxybenzoyl chloride (0.12 mL, 1.0 mmol) afforded, after purification (SiO2: 4:2:1 DCM:EtOAc:isopropyl-amine) and conversion to the HCl salt by general method A, 205 mg (91%) of the title compound.

المصدر