تفاعل #60714

معادلة التفاعل

3-chloro-N-[1-(4-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide

acetone

→

title compound

المردود 76.0%

3-Chloro-N-[1-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide

المردود 76.0%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىafforded

الإجراء التجريبي

Using alkylation method A, 3-chloro-N-[1-(4-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (600 mg, 1.4 mmol) and acetone (10 mL, 135 mmol) afforded, after trituration (acetonitrile), 500 mg (76%) of the title compound.

المصدر