تفاعل #60674

معادلة التفاعل

sodium p-toluensulfinate dihydrate

water benzene acetone

chloroacetone

→

title product

المردود 95.0%

1-(Toluene-4-sulfonyl)-propan-2-one

المردود 95.0%

المذيبات

ethyl acetate n-heptane

ظروف التفاعل

المعالجة

1. 1
   أخرىWas prepared

الإجراء التجريبي

Was prepared according to Crandall et al. J. Org. Chem. 1985, (8) 50, 1327-1329 from sodium p-toluensulfinate dihydrate (4.2 g, 18 mmol), chloroacetone (1.0 mL, 12 mmol), n-tetrabutylammonium bromide (0.30 g) and water-benzene-acetone 4:3:3 (10 mL). Work-up and chromatography on silica of the crude using ethyl acetate/n-heptane (1:3 through 1:2) as eluent gave 2.4 g (95%) of the title product as an oil which crystallised on standing in the fridge.

المصدر