تفاعل #605896

معادلة التفاعل

benzyl piperazine-1-carboxylate

methyl 2-bromoacetate

→

benzyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate

المردود 92.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   تركيزthe reaction mixture was concentrated
2. 2
   أخرىthe residue was partitioned between EtOAc and saturated aqueous NaHCO3
3. 3
   تجفيفThe organic layer was dried over anhydrous magnesium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated

الإجراء التجريبي

To a solution of benzyl piperazine-1-carboxylate (0.5 g, 2.270 mmol) and TEA (0.949 mL, 6.81 mmol) in THF (10 mL) was added methyl 2-bromoacetate (0.230 mL, 2.497 mmol) dropwise. The reaction was stirred at 65° C. After 1 hour, the reaction mixture was concentrated, and the residue was partitioned between EtOAc and saturated aqueous NaHCO3. The organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated to generate benzyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate as a clear oil (0.61 g, 92% yield).

المصدر