تفاعل #60542

معادلة التفاعل

4-(5-fluoro-2-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid t-butyl ester

→

title compound

المردود 99.5%

4-(5-Fluoro-2-methoxyphenyl)piperidine-1-carboxylic acid t-butyl ester

المردود 99.5%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered through Celite
2. 2
   تركيزthe obtained filtrate was concentrated under reduced pressure

الإجراء التجريبي

To a solution of 4-(5-fluoro-2-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid t-butyl ester (2.0 g, 6.5 mmol) produced in Example (106a) in methanol (30 mL) was added 10% palladium on carbon (0.99 g, wet), the mixture was stirred for 17 hours at atmospheric pressure and room temperature under a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the obtained filtrate was concentrated under reduced pressure to give 2.0 g of the title compound as a light yellow oil.

المصدر