تفاعل #604047

معادلة التفاعل

Ethyl 4-fluoro-3-hydroxybenzoate

K2CO3

2,6-Dimethylbenzyl chloride

→

title compound

Ethyl 3-(2,6-dimethylbenzyloxy)-4-fluorobenzoate

المذيبات

DMF

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water (2×), and brine
2. 2
   تجفيفThe organic layer was dried over Na2SO4
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated
5. 5
   أخرىpurified by flash chromatography on a silica gel column (hexane:ethyl acetate, 4:1)

الإجراء التجريبي

To a stirred solution of Ethyl 4-fluoro-3-hydroxybenzoate (2.814 g, 15.3 mmol), K2CO3 (1.95 g, 14.1 mmol) in DMF (15 ml) was added 2,6-Dimethylbenzyl chloride (2.21 g, 14.3 mmol) at room temperature under argon. The reaction mixture was stirred for 16 hours at the room temperature, diluted with ethyl acetate and washed with water (2×), and brine. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hexane:ethyl acetate, 4:1) to give the title compound.

المصدر