تفاعل #60342

معادلة التفاعل

tert-Butyl-chloro-dimethyl-silane

4-chromanol

N-methylmorpholine

imidazole

→

title compound

tert-butyl-(chroman-4-yloxy)-dimethyl-silane

المذيبات

CH2Cl2

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with dilute HCl and H2O
2. 2
   تجفيفdried over MgSO4
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated in vacuo

الإجراء التجريبي

tert-Butyl-chloro-dimethyl-silane (10.54 g, 70 mmol) was added to a CH2Cl2 (200 mL) solution of 4-chromanol (10.00 g, 66.6 mmol), N-methylmorpholine (10.98 mL, 100 mmol) and imidazole (0.20 g, 3 mmol) at 0° C. The mixture was stirred for 3 days at RT. The reaction was diluted with CH2Cl2 (200 mL), washed with dilute HCl and H2O, dried over MgSO4, filtered, and concentrated in vacuo to provide the title compound.

المصدر