تفاعل #60258

معادلة التفاعل

6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid methyl ester

NaOH

→

pure desired product

المردود 39.2%

6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid

المردود 39.2%

المذيبات

ethyl acetate

water

HCl

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe layers are separated
2. 2
   غسيلthe organic layer is washed with brine
3. 3
   تجفيفThe organic layer is dried (MgSO4)
4. 4
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid methyl ester 8b (58 mg, 0.146 mmol) is suspended in EtOH (2 mL) and 1 mL 2 N NaOH is added. After 16 hours, the reaction mixture is diluted with ethyl acetate, water, and 10% HCl solution. The layers are separated and the organic layer is washed with brine. The organic layer is dried (MgSO4) and concentrated under reduced pressure. Trituration with MeOH provides 22 mg (39%) pure desired product.

المصدر