تفاعل #60126

معادلة التفاعل

2-(2,4-dichlorophenyl)-6-chloro-3-nitropyridine

(2-aminoethyl)(6-amino-5-nitro(2-pyridyl))amine

N,N-diisopropylethylamine

→

{2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[6-(2,4-dichlorophenyl)-5-nitro(2-pyridyl)]amine

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated in vacuo
2. 2
   workup.ADDITIONdiluted with water and ethyl acetate
3. 3
   استخلاصThe solution was extracted three times with ethyl acetate
4. 4
   تجفيفdried over sodium sulfate
5. 5
   أخرىpurified by column chromatography
6. 6
   غسيلeluting with 5-10% methanol/methylene chloride

الإجراء التجريبي

1 mmol of 2-(2,4-dichlorophenyl)-6-chloro-3-nitropyridine was taken with 2 mmol of (2-aminoethyl)(6-amino-5-nitro(2-pyridyl))amine and 3 mmol of N,N-diisopropylethylamine in 2 ml of DMF at 80° C. for two hours. The reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The solution was extracted three times with ethyl acetate, dried over sodium sulfate, and purified by column chromatography eluting with 5-10% methanol/methylene chloride to obtain {2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[6-(2,4-dichlorophenyl)-5-nitro(2-pyridyl)]amine.

المصدر