تفاعل #60105

معادلة التفاعل

2,6-dichloro-3-carboxypyridine

N-methylmorpholine

Isopropyl chloroformate

→

crude product

المردود 109.9%

2,6-dichloropyridine-3-carboxamide

المردود 109.9%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe reaction mixture was stirred for 30 min
2. 2
   أخرىbubbled with pure ammonia gas for 2 min.
3. 3
   workup.STIRRINGstirred overnight at room temperature
4. 4
   تركيزThe crude was concentrated under reduced pressure and sodium bisulfate (0.5M, 35 ml)
5. 5
   workup.ADDITIONwas added
6. 6
   workup.STIRRINGwith stirring
7. 7
   استخلاصThe aqueous solution was extracted with ethyl acetate (3×40 ml)
8. 8
   غسيلThe organics was washed with water and brine
9. 9
   تجفيفdried with sodium sulfate

الإجراء التجريبي

A mixture of 2,6-dichloro-3-carboxypyridine (5.73 g, 30 mmole) and N-methylmorpholine (3.6 ml, 33 mmole) in dichloromethane (100 ml) was stirred in an ice-bath for 5 min. Isopropyl chloroformate (4.28 ml, 33 mmole) was added the reaction mixture at 0° C. The reaction mixture was stirred for 30 min and then bubbled with pure ammonia gas for 2 min. and stirred overnight at room temperature. The crude was concentrated under reduced pressure and sodium bisulfate (0.5M, 35 ml) was added with stirring. The aqueous solution was extracted with ethyl acetate (3×40 ml). The organics was washed with water and brine and dried with sodium sulfate to give yellow crude product (6.3 g, 50% pure).

المصدر