تفاعل #600363

معادلة التفاعل

ethyl 2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-4-carboxylate

LiBH4

NaOH

→

title compound

المردود 97.3%

{2-[4-(Trifluoromethoxy)phenyl]-1,3-thiazol-4-yl}methanol

المردود 97.3%

المذيبات

EtOAc

2-MeTHF

THF

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered through a pad of Celite
2. 2
   تركيزconcentrated

الإجراء التجريبي

To a solution of ethyl 2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-4-carboxylate (71 mg, 0.224 mmol) in 2-MeTHF (1 mL) was added 2M LiBH4 (0.224 mL, 0.448 mmol) in THF slowly at RT. After 90 min the mixture was quenched by the addition of 2M NaOH (0.6 mL, 1.200 mmole). The mixture was stirred for 4 hr then diluted with EtOAc, filtered through a pad of Celite and concentrated to give the title compound (60 mg, 97%). 1H NMR (400 MHz, CDCl3): δ 8.00-7.96 (m, 2 H); 7.31-7.25 (m, 2 H); 7.21 (s, 1 H); 4.84 (d, J=5.6 Hz, 2 H); 2.29-2.22 (m, 1 H).

المصدر