تفاعل #60036

معادلة التفاعل

4-(2-imidazolylacetyl)benzenecarbonitrile

N,N-dimethylformamide dimethyl acetal

→

4-[(2E)-3-(dimethylamino)-2-imidazolylprop-2-enoyl]benzenecarbonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىThe DMFDMA was then removed under reduced pressure
2. 2
   أخرىdried under high vacuum for several hours

الإجراء التجريبي

A mixture of 4-(2-imidazolylacetyl)benzenecarbonitrile (0.30 M) and N,N-dimethylformamide dimethyl acetal (DMFDMA) (80 ml) was stirred for 12 h at 75° C. The DMFDMA was then removed under reduced pressure and dried under high vacuum for several hours giving an orange-yellow solid 4-[(2E)-3-(dimethylamino)-2-imidazolylprop-2-enoyl]benzenecarbonitrile in quantitative yield. The enaminone product was typically used without further purification.

المصدر