تفاعل #59969

معادلة التفاعل

( 4j )

2-(((4-(2-(8-ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

3-chloroperbenzoic acid

(+)-1,4-dioxaspiro[4.5]decane-2-methanol

→

title compound

المردود 16.8%

2-(((4-((2S)-1,4-dioxaspiro[4.5]dec-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

المردود 16.8%

ظروف التفاعل

الإجراء التجريبي

The same procedure as in the steps (4f) to (4j) of Example 4 (a reprecipitation operation was not performed in oxidation step with 3-chloroperbenzoic acid) was repeated using (+)-1,4-dioxaspiro[4.5]decane-2-methanol to obtain the title compound (500 mg, total 16.8% yield) as a white solid.

المصدر