تفاعل #59935

معادلة التفاعل

tetrahydrofuran

methyl(2-ethyl-1,3-dioxolan-2-yl) acetate

potassium carbonate

→

title compound

المردود 71.5%

(2-ethyl-1,3-dioxolan-2-yl)methanol

المردود 71.5%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated under reduced pressure, ethyl acetate
2. 2
   workup.ADDITIONwas added to the residue, which
3. 3
   ترشيحwas subjected to NH silica gel pad filtration
4. 4
   تركيزThe filtrate was concentrated under reduced pressure

الإجراء التجريبي

A mixture of methyl(2-ethyl-1,3-dioxolan-2-yl) acetate (1.39 g, 7.94 mmol), potassium carbonate (2.19 g, 15.9 mmol), tetrahydrofuran (20 ml) and water (10 ml) was stirred at room temperature for 6 hours and 50 minutes. The reaction mixture was concentrated under reduced pressure, ethyl acetate was added to the residue, which was subjected to NH silica gel pad filtration. The filtrate was concentrated under reduced pressure to obtain the title compound (0.75 g, 71.5%) as colorless oil.

المصدر