تفاعل #59919

معادلة التفاعل

benzyloxyacetaldehyde

1,3-propanediol

triethyl orthoformate

p-toluenesulfonic acid monohydrate

triethylamine

→

title compound

المردود 58.0%

2-((benzyloxy)methyl)-1,3-dioxane

المردود 58.0%

ظروف التفاعل

المعالجة

1. 1
   تركيزwhich was concentrated
2. 2
   أخرىThe residue was purified by silica gel column chromatography (elution solvent: heptane/ethyl acetate)

الإجراء التجريبي

A mixture of benzyloxyacetaldehyde (3.6 g, 24 mmol), 1,3-propanediol (5.2 ml, 72 mmol), triethyl orthoformate (4 ml, 24 mmol), and p-toluenesulfonic acid monohydrate (414 mg, 2.45 mmol) was stirred at room temperature for 17 hours. To the reaction mixture, triethylamine (669 μl, 4.8 mmol) was added, which was concentrated. The residue was purified by silica gel column chromatography (elution solvent: heptane/ethyl acetate) to obtain the title compound (2.9 g, yield: 58%) as a light yellow oil.

المصدر