تفاعل #598941

معادلة التفاعل

tetrahydrofuran

N-(2,4-bistrifluoromethylphenyl) 3-isocyanatobenzamide

2,2,3,3,3-pentafluoro-n-propanol

triethylamine

→

title compound

المردود 70.0%

N-(2,4-bistrifluoromethylphenyl) 3-[(2,2,3,3,3-pentafluoro-n-propyloxy)carbonylamino]benzamide

المردود 70.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلan organic layer was washed with a 1N sodium hydroxide aqueous solution and 1N hydrochloric acid
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
3. 3
   أخرىThe residue was purified by silica gel column chromatography (eluent; hexane:ethyl acetate=4:1)

الإجراء التجريبي

First, to an anhydrous tetrahydrofuran solution (15 ml) of 0.5 g of N-(2,4-bistrifluoromethylphenyl) 3-isocyanatobenzamide produced in Example 10-1 were added 0.40 g of 2,2,3,3,3-pentafluoro-n-propanol and 0.13 g of triethylamine, and the resultant mixture was stirred at room temperature for 5 hours. The mixture was diluted with ethyl acetate (20 ml), and an organic layer was washed with a 1N sodium hydroxide aqueous solution and 1N hydrochloric acid. The solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (eluent; hexane:ethyl acetate=4:1) to obtain 0.49 g (yield 70%) of the title compound.

المصدر