تفاعل #598373

معادلة التفاعل

Water

4-amino-piperidine-1-carboxylic acid tert-butyl ester

4-fluoro-2-trifluoromethyl-benzonitrile

potassium carbonate

→

desired compound

المردود 68.0%

4-(4-cyano-3-trifluoromethyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

المردود 68.0%

المذيبات

dimethylsulfoxide

ظروف التفاعل

المعالجة

1. 1
   أخرىthe precipitate formed
2. 2
   أخرىis collected

الإجراء التجريبي

A mixture of 4-amino-piperidine-1-carboxylic acid tert-butyl ester (200 mg; 1.0 mmol), 4-fluoro-2-trifluoromethyl-benzonitrile (208 mg; 1.01 mmol) and potassium carbonate (276 mg; 2.0 mmol) in dimethylsulfoxide (3 mL) is heated to 100° C. over night. Water is then added and the precipitate formed is collected to afford the desired compound (250 mg; 0.68 mmol).

المصدر