تفاعل #59656

معادلة التفاعل

4-(2-Phenyl-cyclopropylcarbamoyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

NaOH

→

desired compound

المردود 84.0%

4-(2-phenyl-cyclopropylcarbamoyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

المردود 84.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   تركيز16 h at room temperature, the reaction mixture was concentrated
2. 2
   workup.ADDITIONtreated with EtOAc and 6 N HCl (5 mL)
3. 3
   تجفيفThe organic layer was dried over MgSO4
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was purified by a silica gel column

الإجراء التجريبي

To a solution of 4-(2-Phenyl-cyclopropylcarbamoyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (422 mg, 1 mmol) in THF (2 mL) was added 1 N NaOH (1.5 mL) at 0° C. with stirring. After 30 min at 0° C. and 16 h at room temperature, the reaction mixture was concentrated and treated with EtOAc and 6 N HCl (5 mL). The organic layer was dried over MgSO4 and concentrated. The residue was purified by a silica gel column using CH2Cl2/MeOH (95:5) as eluant to yield the desired compound as a colorless oil (343 mg, 84%).

المصدر