تفاعل #59567

معادلة التفاعل

5-nitro-2-(2-phenylchroman-6-yloxy)pyridine

2-(2-chlorophenyl)chroman-4,6-diol

→

2-(2-Chlorophenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol

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المعالجة

1. 1
   أخرىThe product was recrystallised from 2-propanol

الإجراء التجريبي

2-(2-Chlorophenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(b) starting from 520 mg of 2-(2-chlorophenyl)chroman-4,6-diol (Example 68(b)). The product was recrystallised from 2-propanol. 1H NMR (300 MHz, d6-DMSO) δ: 9.04 (d, 1H, J 2.9 Hz), 8.61 (dd, 1H, J 9.1, 2.9 Hz), 7.68 (dd, 1H, J 7.6, 1.8 Hz), 7.51-7.40 (m, 3H), 7.27 (d, 1H, J 2.9 Hz), 7.23 (d, 1H, J 9.1 Hz), 7.04 (dd, 1H, J 8.8, 2.9 Hz), 6.92 (d, 1H, J 8.8 Hz), 5.59 (d, 1H, J 10.6 Hz), 5.02 (m, 1H), 2.40 (m, 1H), 1.93 (m, 1H).

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