تفاعل #595406

معادلة التفاعل

NH3

3,6-dibromo-9-(oxiran-2-ylmethyl)-9H-carbazole

→

white solid

المردود 65.4%

1-amino-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol

المردود 65.4%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe vial was tightly sealed
2. 2
   أخرىVolatile components were removed under vacuum
3. 3
   ترشيحthe white precipitate was filtered
4. 4
   أخرىCH2Cl2 was removed under vacuum

الإجراء التجريبي

A solution of NH3 (9.4 mL of 7M in MeOH, 65.6 mmol) was added to 3,6-dibromo-9-(oxiran-2-ylmethyl)-9H-carbazole (0.500 g, 1.31 mmol). The vial was tightly sealed and the reaction mixture was heated to 100° C. and stirred for 1 hour. Volatile components were removed under vacuum. The residue was suspended in CH2Cl2 and the white precipitate was filtered. The filtrate was saved and CH2Cl2 was removed under vacuum to afford 0.3413 g white solid as crude product, which contained about 50% unidentified side-product. This crude product was used as is in next step without any further purification. Purification by flash chromatography on silica gel provided pure material.

المصدر